C-type natriuretic peptide upregulates vascular endothelin type B receptors.

C-type natriuretic peptide upregulates vascular endothelin type B receptors.

Cultured rat vascular smooth muscle cells (VSMCs) possess receptors for potent vasoconstrictor endothelin-1 (ET-1) as well as potent vasodilator natriuretic peptides (atrial, brain, and C-type natriuretic peptides [ANP, BNP, and CNP, respectively]). However, little is known about molecular interactions between endothelin receptors and natriuretic peptides in VSMCs. To elucidate whether natriure...

C-type natriuretic peptide and vascular remodeling.

Natriuretic Peptide Type-B Gene

The structure of the mouse natriuretic peptide type-B (BNP) gene was determined by isolating and sequencing genomic clones. The mouse BNP gene was structurally similar to other natriuretic peptide genes and comprised three exons and two introns. Expression of the mouse BNP gene was found only in cardiac tissue as determined by ribonuclease protection analyses. Initiation of transcription was 31...

Cerebral ischemia upregulates vascular endothelin ET(B) receptors in rat.

BACKGROUND AND PURPOSE Elevated levels of endothelin-1 (ET-1) have been reported in cerebral ischemia. A role for ET may prove more important if the vascular receptors were changed. We addressed whether there is any change in ET receptor expression in cerebral ischemia. METHODS The right middle cerebral artery (MCA) was occluded in male Wistar rats for 2 hours with the intraluminal filament m...

Urinary C-Type Natriuretic Peptide

Cardiorenal Research La , Rochester, Minnesota; a innesota. This work was O1 HL36634 and PO1 H tional Research (grant no lingham, Ms. Heublein, D the use of urinary C-type hey have no relationships pt received November 13 cepted December 5, 2012 his study was conducted to determine whether urinary excretion of C-type natriuretic peptide (CNP) is elevated in acute decompensated heart failure (AD...